Quest descriptions often have tips and tricks.
You can put your larger setups in Compact Machines to save space.
Automation is key!
Mekanism Cables tend to cause lag, be careful not to overuse them.
Press "Backspace" to go to the previous recipe in JEI.
The changelog will let you know what has changed between updates.
Instead of using filled buckets in recipes, you can use filled Portable Tanks for batch crafting.
XNet is both cheap and powerful.
Always craft extras.
Beware of your nutrition. (Hotkey N)
Be careful not to spend too long exploring at first, mobs can overwhelm you as the difficulty increases.
The difficulty increases the further you are from spawn.
The difficulty increases whenever you sleep.
Angel of Vengeance is worth leveling up as fast as possible.
To loot a dragon, right-click it with an empty hand.
Thermal Expansion machines may need upgrades in order to craft certain recipes.
OP: The command "/bq_admin default load" reloads the questbook. It will not alter your progress.
OP: The command "/bqs_loot default load" reloads the available loot from Loot Chests.
OP: You can restore a player's inventory after death with the command "/tmg_restore PlayerName latest". You can also cycle through different deaths with the Tab key.
Seemingly random debuffs can stem from a bad diet.
Try to fight the Gaia Guardian before your difficulty reaches 250.
Keep your item cables short. Not only does it speed up the overall transfer, it is also easier on the server.
Some items have JEI descriptions explaining how to obtain them.
Use F7 to see the light levels on the ground and F9 to see the chunk borders.
Press Shift/Sneak over your grave to retrieve your items.
Holding the Drawer Key in your off-hand will automatically lock a newly placed Storage Drawer.